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・ Neohumanism
・ Neohydrocoptus
・ Neohylus
・ Neohyparpalus
・ Neohyperteles
・ Neohypoaspis
・ Neohypodiscus
・ Neoi Epivates
・ Neoi Poroi
・ Neoibidion
・ Neoibidionini
・ Neoichnology
・ Neoicoceratidae
・ Neoicoceratoidea
・ Neointima
Neointimal hyperplasia
・ Neoiphinoe
・ Neoiphinoe arctica
・ Neoiphinoe kroeyeri
・ Neoischnolea papuana
・ Neoism
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・ Neojanacus perplexus
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Neointimal hyperplasia : ウィキペディア英語版
Neointimal hyperplasia
Neointimal Hyperplasia refers to proliferation and migration of vascular smooth muscle cells primarily in the tunica intima, resulting in the thickening of arterial walls and decreased arterial lumen space.〔〔 Neointimal hyperplasia is the major cause of restenosis after percutaneous coronary interventions such as stenting or angioplasty.〔 The term neointima is used because the cells in the hyperplastic regions of the vascular wall have histological characteristics of both intima and normal artery cells.〔

== Causes ==
Neointimal hyperplasia first develops with damage to the arterial wall, followed by platelet aggregation at site of injury, recruitment of inflammatory cells, proliferation and migration of vascular smooth muscle cells, and collagen deposition.〔
Mechanical injury of arterials due to stretching of arterial walls with a balloon catheter results in the recruitment of cells such as monocytes, macrophages, and neutrophils to the site of injury.〔〔 Macrophages in particular express many growth factors, cytokines, and enzymes that facilitate vascular smooth muscle cell migration and proliferation.〔
C-reactive protein is a systemic inflammatory mediator correlated with neointimal hyperplasia, but it is still unknown if this protein is a marker of increased risk or a causative agent of the condition.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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